New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands
نویسندگان
چکیده
منابع مشابه
New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands.
Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melato...
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Heterodimerization has been documented for several members of the G protein-coupled receptor (GPCR) superfamily, including the closely related MT1 and MT2 melatonin receptors. However, the relative abundance of heteroversus homodimers and the specific properties, which can be attributed to each form, are difficult to determine. Using a bioluminescence resonance energy transfer (BRET) donor satu...
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ژورنال
عنوان ژورنال: Molecules
سال: 2012
ISSN: 1420-3049
DOI: 10.3390/molecules17077737